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EFFECTS OF CORTISOL ON BLOOD PRESSURE AND SALT PREFERENCE IN NORMAL HUMANS
Author(s) -
Wong K. S.,
Williamson P. M.,
Brown M. A.,
Zammit V. C.,
Denton D. A.,
Whitworth J. A.
Publication year - 1993
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1993.tb00584.x
Subject(s) - blood pressure , endocrinology , medicine , taste , appetite , sodium , hormone , adrenocorticotropic hormone , chemistry , food science , organic chemistry
SUMMARY 1. Adrenocorticotrophic hormone (ACTH) and corticosteroids stimulate salt appetite in laboratory animals. The hypothesis tested was that cortisol administration increases salt preference in humans. 2. Sodium taste studies (detection and recognition thresholds, taste intensity and preference tests) were conducted before, during and after cortisol administration (200 mg/day for 5 days) in normal men on a free diet. 3. Cortisol significantly increased systolic blood pressure (SBP), 113 ± 3–130±4 mmHg, P < 0.05; diastolic blood pressure (DBP), 65±3–81±2 mmHg, P < 0.05; mean arterial pressure (MAP), 81± 2–97± 3 mmHg, P < 0.05; and bodyweight, 72.9±3.0–75.4±3.3 kg, P < 0.05. 4. Salt detection and recognition thresholds, taste intensity and preference for sodium chloride were unchanged following cortisol.