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CIRCULATING LEVELS OF ACTIVE, TOTAL AND INACTIVE RENIN (PRORENIN), ANGIOTENSIN I AND ANGIOTENSINOGEN IN CARBON TETRACHLORIDE‐TREATED RATS
Author(s) -
Cruz Cristino,
IbarraRubio Maria Elena,
PedrazaChaverrí José
Publication year - 1993
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1993.tb00579.x
Subject(s) - plasma renin activity , medicine , endocrinology , renin–angiotensin system , carbon tetrachloride , chemistry , renal function , creatinine , angiotensin ii , blood pressure , organic chemistry
SUMMARY 1. Plasma renin activity (PRA), plasma angiotensin I concentration (ANG I), plasma angiotensinogen concentration (PAC) and the plasma levels of active, total and inactive renin (prorenin) were measured in rats with carbon tetrachloride (CCl 4 )‐induced acute renal failure. Rats were treated with a single oral dose of CCl 4 (2.5 mL/kg) and killed 1, 2, 3 and 7 days later. 2. On days 1–3 PRA, ANG I and PAC decreased and increased on day 7. Active renin fell on days 2 and 3, total renin (trypsin treatment) augmented on day 1 and diminished on day 3, prorenin and per cent prorenin increased on days 1 and 2. Angiotensin I concentration paralleled PRA and PAC. The CCl 4 ‐induced decrease in PRA was secondary to the fall in active renin and in PAC. Total renin augmented as a consequence of the elevation of prorenin. Renal function, evaluated by serum urea, serum creatinine and creatinine clearance, decreased on days 1 and 2 when PRA was low and plasma prorenin was high. 3. These data do not support the involvement of the circulating active renin‐angiotensin system (RAS) in the pathophysiology of acute renal failure induced by CCl 4 , however, increased prorenin levels were associated with the decrease in renal function.