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DIABETIC RAT AORTA RESPONSIVENESS TO D600 AND NIFEDIPINE
Author(s) -
Orie N. N.,
Aloamaka C. P.
Publication year - 1993
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1993.tb00578.x
Subject(s) - nifedipine , aorta , medicine , gallopamil , streptozotocin , endocrinology , analysis of variance , diabetes mellitus , calcium
SUMMARY 1. The responsiveness of aortic rings from 4 and 12 week streptozotocin‐induced diabetic rats to D600 (Gallopamil) and nifedipine was studied. 2. The sensitivity and responsiveness to D600 were significantly enhanced ( P < 0.05; 5‐test, ANOVA; 9 d.f.) only in the 4 week diabetic preparations precontracted with noradrenaline. 3. Nifedipine‐induced relaxations were significantly enhanced ( P < 0.05–0.01; t ‐test, ANOVA; 8–12 d.f.) in all the diabetic (4 and 12 weeks) aortic preparations precontracted with both noradrenaline (10 ‐7 mol/L) and KCl (40 mmol/L) when compared with controls. 4. D600, unlike nifedipine, did not produce significant relaxation of diabetic aortic preparations precontracted with KCl (40 mmol/L) at both week 4 and 12 of the disease when compared with controls. 5. These results suggest that there is differential responsiveness of streptozotocin diabetic rat aorta to D600 and nifedipine.