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THE TISSUE RENIN‐ANGIOTENSIN SYSTEM AND ITS FUNCTIONAL ROLE
Author(s) -
Johnston C. I.,
Burrell L. M.,
Perich R.,
Jandeieit K.,
Jackson B.
Publication year - 1992
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1992.tb02802.x
Subject(s) - renin–angiotensin system , medicine , muscle hypertrophy , hyperplasia , endocrinology , stimulation , angiotensin converting enzyme , somatic cell , biology , blood pressure , biochemistry , gene
SUMMARY 1. The components of the renin‐angiotensin system exist in many cardiovascular tissues (heart vessels, kidneys, adrenal glands). 2. Angiotensin‐converting enzyme (ACE) is similar in somatic cells from all these sites. 3. ACE contains two catalytic sites that have different conformation requirements. This suggests that each site may have different substrates and that specific inhibitors could be developed for each site. 4. The cardiovascular functions of tissue ACE may include the regulation of regional blood flow, modulation of local sympathetic activity, stimulation of hyperplasia and hypertrophy and the mediation of inflammation.