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ENHANCEMENT BY ENDOTHELIN‐1 OF THE RELEASE OF CATECHOLAMINES FROM THE CANINE ADRENAL GLAND IN RESPONSE TO SPLANCHNIC NERVE STIMULATION
Author(s) -
Takeuchi Akihiko,
Kimura Tomohiko,
Satoh Susumu
Publication year - 1992
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1992.tb00519.x
Subject(s) - splanchnic nerves , adrenal gland , medicine , endocrinology , endothelin receptor , splanchnic , stimulation , adrenal medulla , endothelin 1 , endothelins , catecholamine , basal (medicine) , blood flow , chemistry , receptor , insulin
SUMMARY 1. The effect of endothelin‐1 on the release of adrenal catecholamines was examined in anaesthetized dogs. 2. Splanchnic nerve stimulation (SNS) at 1 and 3 Hz was applied before and after the intravenous injection of endothelin‐1. 3. Endothelin‐1 (0.1 and 0.3 μg/kg) significantly enhanced the release of adrenal catecholamines induced by 3 Hz SNS, but did not affect basal release and the release of adrenal catecholamines induced by 1 Hz SNS. 4. Endothelin‐1 produced a slight and short‐lasting fall in arterial blood pressure and decreases in adrenal and renal blood flow rates. 5. These results indicate that endothelin‐1 enhances the release of adrenal catecholamines from the canine adrenal gland in response to relatively high frequency SNS.