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INTRACORONARY PGE 2 AND VERATRINE INHIBITS RENIN RELEASE IN CONSCIOUS DOGS VIA CHEMOSENSITIVE VENTRICULAR AFFERENTS
Author(s) -
Gorman A. J.,
Chen JS.,
Foster S.,
Snyder R. G.,
Lams S. G.
Publication year - 1992
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1992.tb00517.x
Subject(s) - renin–angiotensin system , carnivora , medicine , cardiology , fissipedia , anesthesia , blood pressure
SUMMARY 1. Prostaglandins (PG) and veratrum alkaloids stimulate ventricular sensory receptors with non‐myelinated vagal afferents and mediate inhibitory circulatory responses. 2. The present study in conscious instrumented dogs was carried out to determine the effects of intracoronary artery infusions of veratrine (Ver‐IC) and PGE 2 (PGE 2 ‐IC) on plasma renin activity (PRA). 3. A 15‐20 mmHg decrease in arterial pressure was produced during Ver‐IC (0.2–0.8 μg/kg per min) and PGE 2 ‐IC (10‐50 ng/kg per min), but there was no change in PRA or heart rate. 4. In contrast, significant increases in PRA (+ 3.51 ± 0.37 ng angiotensin 1/mL per h; P < 0.01) and heart rate (+ 38.5 ± 6.2 beats/min; P < 0.001) were elicited in response to a 15–20 mmHg decrease in arterial pressure produced by intravenous infusions of nitroprusside. 5. Pharmacological blockade of afferent fibres in the pericoronary region of the left main coronary artery during Ver‐IC resulted in significant hypotension‐induced increases in PRA ( P < 0.001) and heart rate ( P < 0.001), thus removing the inhibitory influence of chemosensitive ventricular afferents. 6. Therefore, intracoronary veratrum alkaloids and prostaglandins inhibit hypotension‐induced increases in PRA and heart rate in the conscious dog. This is mediated by chemosensitive receptors located in the left ventricular myocardium along with afferent nerves in the pericoronary region and cervical vagi.