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AGEING HAS NO EFFECT ON THE VOLUME DENSITY OF HEPATOCYTES, RETICULOENDOTHELIAL CELLS OR THE EXTRACELLULAR SPACE IN LIVERS OF FEMALE SPRAGUE‐DAWLEY RATS
Author(s) -
Martin G.,
Sewell R. B.,
Yeomans N. D.,
Smallwood R. A.
Publication year - 1992
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1992.tb00501.x
Subject(s) - extracellular , mononuclear phagocyte system , ageing , population , endocrinology , medicine , stereology , cell , chemistry , extracellular fluid , perisinusoidal space , biology , andrology , hepatocyte , microbiology and biotechnology , immunology , biochemistry , in vitro , environmental health
SUMMARY 1. The hepatic reticuloendothelial cell population is generally assumed to increase in size, along with the liver, during ageing in rats. However, this has not been rigorously established. 2. Using electron microscopy and stereological techniques, the present study has shown that the volume densities of hepatocytes and Kupffer cells (and probably also of endothelial cells, fat storing cells and the extracellular space) of the livers of female Sprague‐Dawley rats are the same at 2 and 24–25 months of age. 3. This result indicates that the increase in size of the liver during ageing in the rat is associated with an equivalent increase in the volume of each cell population and the extracellular space.