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DIFFERENTIAL REGULATION BY TRANSFORMING GROWTH FACTOR‐β1 OF PLATELET‐DERIVED GROWTH FACTOR‐ STIMULATED PROLIFERATION OF VASCULAR SMOOTH MUSCLE CELLS FROM SHR AND WKY RATS
Author(s) -
Saltis John,
Agrotis Alex,
Bobik Alex
Publication year - 1992
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1992.tb00481.x
Subject(s) - transforming growth factor , endocrinology , medicine , vascular smooth muscle , growth factor , muscle hypertrophy , cell growth , platelet derived growth factor , transforming growth factor beta , platelet , smooth muscle , chemistry , biology , platelet derived growth factor receptor , receptor , biochemistry
SUMMARY 1. This study has examined and compared the time‐course of action of transforming growth factor‐β1 (TGF‐β1) on platelet‐derived growth factor‐BB‐stimulated proliferation of vascular smooth muscle cells isolated from normotensive Wistar‐Kyoto (WKY) rats and spontaneously hypertensive rats (SHR). 2. Transforming growth factor‐β1 inhibited vascular smooth muscle cell proliferation stimulated by platelet‐derived growth factor‐BB in WKY rats by approximately 60–75%. 3. In contrast, transforming growth factor‐β1 potentiated an 8–35% growth factor action on cell proliferation in the SHR. 4. Defects in transforming growth factor‐β1 action may be part of the molecular mechanism responsible for the development of vascular hypertrophy in the SHR.