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DA‐1 RECEPTORS MEDIATE RENAL EFFECTS OF THE DOPAMINE PRODRUG, GLUDOPA, IN CONSCIOUS RABBITS
Author(s) -
Wang ZhiQin,
Way Diana,
Trigg Lisbeth,
McGrath Barry P.
Publication year - 1992
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1992.tb00474.x
Subject(s) - natriuresis , endocrinology , medicine , renal blood flow , diuresis , plasma renin activity , chemistry , vasodilation , renal artery , dopamine , kidney , angiotensin ii , renin–angiotensin system , blood pressure
SUMMARY 1. Eight male rabbits were implanted with Doppler flow probes around the lower abdominal aorta and left renal artery. A 2 week recovery period was allowed prior to the experiment. 2. Normal saline, gludopa at 25 μmg/kg per min and at 100 μg/ kg per min were each infused i.v. for 60 min. One week later the same protocol was administered to four of these animals in addition to DA‐1 antagonist SCH 23390 (0.3 mg/kg i.v.) before gludopa infusion. 3. Gludopa elicited significant increases in urine flow, urinary sodium excretion and renal blood flow, and decreased renal vascular resistance. These changes were abolished by the DA‐1 antagonist. Blood pressure, heart rate and hindlimb blood flow remained unchanged. 4. Urine dopamine excretion was increased 1200‐fold and 7800‐fold after gludopa administration at 25 μg/kg per min and 100 μg/kg per min, respectively, while plasma dopamine concentration and plasma renin activity (PRA) were not significantly altered. However, PRA was elevated by gludopa with DA‐1 antagonism. 5. The renal vasodilation, natriuresis and diuresis produced by gludopa in conscious rabbits appears to be mediated by locally generated dopamine via DA‐1 receptors.