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CONCURRENCE OF PRIMARY ALDOSTERONISM AND RENAL ARTERY STENOSIS
Author(s) -
Stokes Gordon S.,
Monaghan Judith C.,
Roche James,
Grunstein Harry,
Gordon Richard D.
Publication year - 1992
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1992.tb00457.x
Subject(s) - medicine , hyperaldosteronism , primary aldosteronism , renal artery stenosis , hyperplasia , aldosterone , adrenalectomy , renal artery , stenosis , secondary hypertension , adrenal gland , urology , renal artery obstruction , kidney , endocrinology , blood pressure
SUMMARY 1. An unusual clinical case is described in which renal artery stenosis (RAS) was found to coexist with adrenocortical hyperplasia, resulting in hypertension. 2. Partial relief of the hypertension was achieved by correction of RAS, and then further relief by extirpation of one adrenal gland affected by unilateral hyperplasia, in interventions 8 months apart. 3. Biochemical features typical of primary hyperaldosteronism were observed both before and after RAS repair but were not present after unilateral adrenalectomy. 4. The association of these two lesions could have occurred by chance, through genetic linkage, or by progression from RAS to tertiary aldosteronism.