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POTASSIUM CHANNEL ACTIVATION IMPROVES BLOOD FLOW PATTERN OF CONSCIOUS RATS IN CUTANEOUS MICROCIRCULATION
Author(s) -
Hertel RolfF.
Publication year - 1992
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1992.tb00445.x
Subject(s) - microcirculation , perfusion , blood flow , chemistry , potassium , hemodynamics , potassium channel , blood pressure , peripheral , medicine , anatomy , endocrinology , anesthesia , organic chemistry
SUMMARY 1. A dose‐dependent mean arterial blood pressure reduction (tailcuff method) to an intravenously administered potassium channel activator (22 or 24 μg/ kg bw) was found in conscious rats. 2. Intravital microscopic analysis of skin microcirculation in conscious rats was performed with respect to erythrocyte flow velocity and diameters of capillaries. There was a dose‐dependent increase of erythrocyte flow velocity; diameters of capillaries were dilated following a dosage of 6 and 12 Mg/kg bw, but constricted following a dosage of 24 μg/kg bw. 3. Frequency distributions of velocity ranges in capillaries under observation (real time video recordings) proved that the increase of microvascular perfusion is manifested by a shift of maximal values to increasing velocity ranges. 4. It is concluded that potassium channel activation plays an important role in the local regulation of perfusion on the peripheral circulation.