Premium
SODIUM AND NORADRENALINE IN CEREBROSPINAL FLUID AND BLOOD IN SALT‐SENSITIVE AND NON‐SALT‐SENSITIVE ESSENTIAL HYPERTENSION
Author(s) -
Kawano Yuhei,
Yoshida Kaoru,
Kawamura Minoru,
Yoshimi Hiroki,
Ashida Terunao,
Abe Hitoshi,
Imanishi Masahito,
Kimura Genjiro,
Kojima Shunichi,
Kuramochi Morio,
Omae Teruo
Publication year - 1992
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1992.tb00444.x
Subject(s) - cerebrospinal fluid , salt (chemistry) , sodium , sodium salt , essential hypertension , chemistry , medicine , endocrinology , blood pressure , inorganic chemistry , organic chemistry
SUMMARY 1. The effects of dietary sodium on blood pressure and levels of sodium, other electrolytes and noradrenaline (NA) in the cerebrospinal fluid (CSF) and blood of 15 patients with essential hypertension were studied. The CSF and blood sampling was carried out after 7 days of a high salt intake (16–18 g/day) and after 7 days of a low salt intake (1–3 g/day). 2. Blood pressure and sodium concentrations in CSF and serum were significantly higher in the high salt period than the low salt period (CSF Na + concentration: 147.7 ± 0.4 mmol/L vs 145.3 ± 0.5 mmol/L; P < 0.001). Levels of CSF pressure and potassium or calcium concentrations were not different between the two periods. Plasma NA and plasma renin activity (PRA) were lower and CSF NA levels tended to be lower in the high salt period. 3. The levels and the changes in sodium and NA in CSF were not significantly different between the salt‐sensitive ( n = 8) and the non‐salt‐sensitive ( n = 7) subjects, but the changes in plasma NA and PRA were smaller in the salt‐sensitive subjects. 4. These results indicate that the sympathetic nervous system is less suppressed in salt‐sensitive subjects during high salt intake. This may be due to altered neural responsiveness to sodium loading rather than being greater increases in sodium concentration in the central nervous system.