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PROPOFOL ANAESTHESIA IN MALIGNANT HYPERPYREXIA SUSCEPTIBLE SWINE
Author(s) -
Foster P. S.,
Hopkinson K. C.,
Denborough M. A.
Publication year - 1992
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1992.tb00436.x
Subject(s) - propofol , medicine , halothane , anesthesia , muscle contracture , contracture , sedative , muscle relaxant , general anaesthesia , sedation , surgery
SUMMARY 1. Malignant hyperpyrexia (MH) is an inherited muscle abnormality that presents clinically as a syndrome of life‐threatening complications during general anaesthesia. 2. Propofol is a new sedative hypnotic used for the induction and maintenance of anaesthesia. 3. Propofol did not induce MH in five susceptible pigs. Propofol did not induce contracture in isolated MH susceptible muscle but did modify halothane, caffeine and KCl contractures.