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PLASMA PHOSPHOLIPASE A 2 ACTIVITY IN CLINICAL ACUTE MYOCARDIAL INFARCTION
Author(s) -
Leong Lillian L. L.,
Sturm Marian J.,
Ismail Yahya,
Stephens Charlene J.,
Taylor Roger R.
Publication year - 1992
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1992.tb00429.x
Subject(s) - myocardial infarction , cardiology , medicine , phospholipase , chemistry , biochemistry , enzyme
b 1. Phospholipase A 2 (PLA 2 ) cleaves phospholipids to produce a lyso‐phospholipid and free fatty acid and, in view of the biological activity of the products, PLA 2 may play a role in many disease states. Lyso‐phospholipids and free arachidonic acid increase in ischaemic myocardium, indicating that ischaemia activates the enzyme. 2. Plasma PLA 2 activity was measured in patients with acute myocardial infarction, based on the release of labelled arachidonic acid from Escherichia coli cell membrane. Fourteen males (peak serum creatine phosphokinase (CK) above twice upper normal) were studied on day 1 (within 6 h of chest pain onset), days 2–4, and days 6–9. Normal age matched males ( n = 13) were also studied. 3. Plasma PLA 2 in patients with uncomplicated myocardial infarction ( n = 12) was, initially, 1.14±0.10 (s.e.m.) nmol/min per mL plasma, similar to that in the normal group (1.52 ± 0.14). On days 2–4, PLA 2 activity increased to 1.94±0.18( P <0.001) and this activity was correlated with the earlier peak CK level ( P <0.02). On days 6–9, PLA 2 activity was 1.49±0.13 while in two patients who developed complications and underwent open‐heart surgery between the last two measurements, there were further increases to 4.22 and 4.04 nmol/min per mL. 4. The increase in plasma PLA 2 in uncomplicated myocardial infarction is likely to be due to release from the damaged myocardium; whether it contributes to pathophysiology is uncertain.