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CYCLIC ADENOSINE 3′,5′‐MONOPHOSPHATE CONTENT AND BRONCHIAL SMOOTH MUSCLE CONTRACTILITY OF HYPER‐ AND HYPOTHYROID LUNGS
Author(s) -
Nabishah B. M.,
Morat P. B.,
Alias A. K.,
Kadir B. A.,
Khalid B. A. K.
Publication year - 1992
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1992.tb00423.x
Subject(s) - contractility , medicine , endocrinology , adenosine , adenosine monophosphate , respiration , thiouracil , chemistry , thyroid , anatomy
SUMMARY 1. Male Sprague‐Dawley rats were made either hyper‐ or hypothyroid with thyroxine or 4‐methyl‐2‐thiouracil, respectively. Bronchial smooth muscle (BSM) contractility and lung cyclic adenosine 3′,5′‐monophosphate (cAMP) content were measured in both conditions. 2. Bronchial smooth muscle contractility was significantly weaker in hyperthyroid rats, while the BSM contractility of hypothyroid rats was the same as controls. 3. The cAMP content of hyperthyroid rat lungs was similar to controls but was decreased in hypothyroid rats. 4. These studies demonstrated that both the hyper‐ and hypothyroid states affect respiration, although the mechanisms involved with different for each condition.