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ENDOTHELIN‐3‐INDUCED MICROVASCULAR INCOMPETENCE AND MITOCHONDRIAL DAMAGE IN RAT MYOCARDIUM
Author(s) -
Maxwell Linda,
Pratt Katherine,
Gavin John
Publication year - 1992
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1992.tb00404.x
Subject(s) - cardiology , perfusion , endothelin receptor , medicine , endothelin 1 , myocyte , microcirculation , endocrinology , receptor
SUMMARY 1. To determine the possible role of an endothelin in the development of postischaemic microvascular incompetence, isolated buffer‐perfused rat hearts were perfused with endothelin‐3 (ET‐3) in phosphate buffer. 2. ET‐3 produced a reduction in coronary flow rate, heart rate and arrhythmia. There was a marked reduction in the density of competent capillaries, and the myocytes showed vacuolation and mitochondrial damage in regions where microvascular incompetence was most severe. 3. These results indicate that ET‐3 can substantially reduce microvascular perfusion in the heart and can also cause damage to the myocyte.