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INTRACELLULAR pH AND SODIUM‐PROTON EXCHANGE ACTIVITY OF LYMPHOCYTES IN STROKE‐PRONE SPONTANEOUSLY HYPERTENSIVE RATS
Author(s) -
Diyuan Li,
Kobayashi Ayame,
Nara Yasuo,
Ikeda Katsumi,
Mori Chuzo,
Yamori Yukio
Publication year - 1991
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1991.tb01630.x
Subject(s) - intracellular , sodium , intracellular ph , chemistry , stroke (engine) , medicine , endocrinology , biophysics , biochemistry , biology , mechanical engineering , organic chemistry , engineering
SUMMARY 1. At the age of 20 weeks, intracellular pH (pH i ) of circulating lymphocytes suspended in HCO 3 − ‐free NaCl media was not significantly different between stroke‐prone spontaneously hypertensive rats (SHRSP) and normotensive Wistar‐Kyoto rats (WKY). 2. The initial recovery rate of pH i in lymphocytes tended to be greater in SHRSP than in WKY after the addition of 60 mmol/L or 120 mmol/L of NaCl, but there was no statistically significant difference. 3. The H + equivalent efflux rate, which was a true reflection of Na + ‐H + activity, was significantly greater in SHRSP than in WKY ( P <0.05). The difference in H + equivalent efflux rate was not due to the difference in cellular buffering power between the two groups ( P >0.05). An increased Na + ‐H + exchange activity may play a partial role in the pathogenesis of hypertension.