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THE SYNDROME OF HYPERTENSION AND HYPERKALAEMIA WITH NORMAL GLOMERULAR FILTRATION RATE: IS THERE A DEFICIENCY IN VASODILATOR PROSTAGLANDINS?
Author(s) -
Klemm Shelley A.,
Hornych Antonin,
Tunny Terry J.,
Gordon Richard D.
Publication year - 1991
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1991.tb01452.x
Subject(s) - medicine , endocrinology , reabsorption , vasodilation , renal function , pathophysiology , diuretic , aldosterone , renin–angiotensin system , prostaglandin , urinary system , kidney , blood pressure
SUMMARY 1. In Gordon's syndrome (GS; a syndrome of hypertension and hyperkalaemia with normal glomerular fitration rate), excessive proximal sodium reabsorption leads to suppression of renin and aldosterone, hyperkalaemia and hyperchloraemic acidosis. 2. Low urinary levels of vasodilator prostaglandins (PG) have been reported in GS, suggesting renal hypoprostaglandinism as a pathophysiological mechanism. 3. In four cases of GS, levels of vasodilator prostaglandins PGE 2 and 6‐keto‐PGF 1α were low. 4. In one case of GS, low PGE 2 levels were normalized by dietary salt restriction or diuretic therapy.