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ROLE OF THE SYMPATHETIC NERVOUS SYSTEM IN THE ONSET OF HYPERTENSION IN THE RAT: THE EFFECT OF 6‐OH‐DOPAMINE
Author(s) -
Li Ming,
Whitworth Judith A.
Publication year - 1991
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1991.tb01432.x
Subject(s) - sympathectomy , endocrinology , medicine , blood pressure , dopamine , urine , sympathetic nervous system , catecholamine , excretion , chemistry
SUMMARY 1. The effect of chemical sympathectomy with 6‐OH‐dopamine (6‐OHDA) on the onset of adrenocorticotrophin (ACTH)‐induced hypertension was examined in Sprague–Dawley rats ( n = 23). 2. 6‐OHDA injection produced a fall in systolic blood pressure (SBP) from 100±5 mmHg control to 74±4 mmHg post‐6‐OHDA Treatment Day 1 ( P <0.001), but did not alter food or water intake, urine volume or electrolyte excretion. 3. Compared with sham injection, ACTH‐treated rats showed an increase in blood pressure (sham: 98±7 mmHg; ACTH: 123±9 mmHg on Treatment Day 10; P <0.01), loss of bodyweight, and increases in water intake and urine volume. 4. The magnitude of the blood pressure rise on ACTH was greater in 6‐OHDA‐treated rats than in intact control rats. Metabolic changes were similar. 5. Chemical sympathectomy with 6‐OHDA did not delay or block the onset of ACTH hypertension in the rat.