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ENDOTHELIN‐1 ENHANCES VASOCONSTRICTOR RESPONSES TO SYMPATHETIC NERVE STIMULATION AND NORADRENALINE IN THE RABBIT EAR ARTERY
Author(s) -
WongDusting Helen K.,
La Mylinh,
Rand Michael J.
Publication year - 1991
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1991.tb01423.x
Subject(s) - stimulation , vasoconstrictor agents , vasoconstriction , endothelin receptor , medicine , vasomotor , endocrinology , endothelin 1 , perfusion , chemistry , sympathetic nervous system , blood pressure , receptor
SUMMARY 1. In rabbit isolated perfused ear arteries denuded of endothelium, a low concentration of endothelin‐1 (0.1 nmol/L) that had no direct vasoconstrictor action produced slowly developing enhancements of vasoconstrictor responses to noradrenaline and sympathetic nerve stimulation. The enhancements reached maximal levels after 60 min of exposure to endothelin‐1. 2. A higher concentration of endothelin‐1 (1 nmol/L), which produced a slow‐developing increase in perfusion pressure of 70 mmHg over the course of 1 h, significantly enhanced vasoconstrictor responses to sympathetic nerve stimulation for the first 30 min, after which there was no significant enhancement. Responses to noradrenaline were not enhanced by 1 nmol/L endothelin‐1. 3. The enhancing effect of low concentrations of endothelin‐1 on vasoconstrictor responses to sympathetic nerve stimulation and noradrenaline may play a physiological role in modulating vasomotor function.