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IONIC MECHANISMS REGULATING SODIUM ENTRY INTO VASCULAR SMOOTH MUSCLE
Author(s) -
Bobik Alex,
Little Peter J.,
Neylon Craig B.
Publication year - 1991
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1991.tb01419.x
Subject(s) - vascular smooth muscle , sodium , dids , chemistry , intracellular , extracellular , biophysics , microbiology and biotechnology , intracellular ph , medicine , endocrinology , biochemistry , biology , smooth muscle , membrane , organic chemistry
SUMMARY 1. Na+/H+ exchange, an ethylisopropylamiloride (EIPA)‐sensitive Na+ and HCO 3 ‐ dependent system and a diisothio‐cyanatostilbenedisulphonic acid (DIDS)‐sensitive Na+ and HCO 3 ‐ transporter, contribute to sodium influx and intracellular pH (pH i ) regulation in vascular smooth muscle. 2. In cultured cells from the human internal mammary artery, Na+/H+ exchange and the EIPA‐sensitive Na+ and HCO 3 ‐ dependent system contribute about 80% to basal sodium influx. The residual Na+ influx is both EIPA and DIDS‐insensitive. 3. Sodium influx via these mechanisms influences the ability of vascular smooth muscle to synthesize protein late in the G 1 phase of the mitotic cell cycle. This, in turn, affects DNA biosysthesis. 4. These Na+ exchanges/transporters have the capability to facilitate the development of vascular hypertrophy in hypertension.