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ADRENALINE RELEASE BY THE HUMAN HEART
Author(s) -
Esler Murray,
Eisenhofer Graeme,
Dart Anthony,
Chin Jaye,
Cox Helen,
Lambert Gavin,
Jennings Garry
Publication year - 1991
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1991.tb01408.x
Subject(s) - supine position , isometric exercise , medicine , epinephrine , norepinephrine , heart rate , catecholamine , endocrinology , cardiac output , cardiology , hemodynamics , blood pressure , dopamine
SUMMARY 1. Radiotracer methods were used to measure the rates of regional release of adrenaline and noradrenaline to plasma in humans. 2. No release of adrenaline could be detected from the heart, lungs, liver and kidneys at rest. 3. With the relatively mild activation of the cardiac sympathetic outflow associated with mental challenge and isometric exercise, cardiac adrenaline release remained undetectable. 4. During supine bicycle exercise, which increased cardiac noradrenaline release 10–20 fold, to a mean value of 128 ng/min, cardiac adrenaline release averaged 1.63 ng/min. 5. Whether neuronal adrenaline release of this degree in the heart is sufficient to facilitate noradrenaline release and to augment sympathetically mediated cardiac responses remains to be tested.