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THE ACTIONS OF TULOBUTEROL ON ISOLATED PREPARATIONS OF GRAVID HUMAN MYOMETRIUM
Author(s) -
Ziccone S. P.,
Paull J. D.
Publication year - 1990
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1990.tb01364.x
Subject(s) - myometrium , medicine , chemistry , pharmacology , uterus
SUMMARY 1. The effects of tulobuterol (Abbott 54173) on the contractile force developed by electrically stimulated strips of gravid (gestation 36–40 weeks) human uterine muscle were compared with those of isoprenaline and adrenalin. 2. Isoprenaline produced inhibition of electrically evoked contractions of myometrium from 12 of 17 women at concentrations at or below 1 μmol/L (range 0.001–1 μmol/L). It enhanced contractions at concentrations of 10–50 μmol/L. In tissues from the remaining five women isoprenaline produced neither inhibitory nor excitatory effects. Adrenalin (0.1–50 μmol/L) was found to enhance contractile force in a concentration‐dependent manner (EC 50 = 0.30 μmol/L). 3. In the presence of metoprolol (0.3 μmol/L), a selective antagonist at β 1 ‐adrenoceptors, the isoprenaline concentration‐response relationship was shifted to the left, indicating that β‐adrenoceptors are present and that they mediate excitation in the human uterus. 4. In contrast tulobuterol (in neither the presence nor absence of metoprolol), in the same concentration range as isoprenaline and adrenalin, (0.001–50 μmol/L) was found to have no effect on the electrically evoked contraction of gravid human uterine muscle strips.