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EVIDENCE FOR THE INHIBITORY EFFECT OF 5‐HYDROXYTRYPTAMINE AT CENTRAL AND PERIPHERAL SITES ON OVULATION IN RABBITS
Author(s) -
Mishra N.,
Tangri K. K.,
Bhargava K. P.,
Gupta M. L.
Publication year - 1990
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1990.tb01360.x
Subject(s) - ovulation , endocrinology , medicine , induced ovulation , inhibitory postsynaptic potential , chemistry , peripheral , subcutaneous injection , andrology , hormone
SUMMARY 1. The effect of 5‐hydroxytryptamine (5‐HT) has been investigated on ovulation per se as well as on induced ovulation in rabbits. 2. 5‐HT administered intracerebroventricularly (i.c.v.) did not induce ovulation per se . 3. The ovulation was induced by coitus, subcutaneous administration of progesterone and intravenous administration of cupric acetate. 4. Postcoital and progesterone induced ovulation was found to be blocked by i.c.v. administered 5‐HT. 5. Cupric acetate induced ovulation was, however, not found to be blocked by i.c.v. administered 5‐HT. 6. Intraperitoneal administration of 5‐HT was found to block cupric acetate induced ovulation. 7. It is concluded that 5‐HT exerts an inhibitory control over ovulation by acting at central as well as at peripheral sites in rabbits.