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EFFECT OF DIMETHYLSULPHOXIDE ON CYSTEAMINE‐INDUCED DUODENAL ULCERATION IN RATS
Author(s) -
Ali B. H.
Publication year - 1990
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1990.tb01345.x
Subject(s) - cysteamine , medicine , chemistry , mucus , subcutaneous injection , endocrinology , pharmacology , biology , ecology
1. Rats were pretreated with dimethylsulphoxide (DMSO) at concentrations of 2, 4 and 6% v/v in the drinking water for 7 days, then injected with a single subcutaneous dose of cysteamine (28 mg/100 g bodyweight) to induce duodenal ulceration. 2. DMSO reduced, in a dose‐dependent manner, the incidence and extent of the ulceration. 3. Mucus duodenal content was not significantly affected by either DMSO or cysteamine treatments.