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EFFECTS OF ATRIAL NATRIURETIC PEPTIDE ON PHENYLEPHRINE‐INDUCED RENIN RELEASE IN DOGS
Author(s) -
Tomura Y.,
Hisa H.,
Satoh S.
Publication year - 1990
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1990.tb01335.x
Subject(s) - phenylephrine , atrial natriuretic peptide , medicine , renin–angiotensin system , propranolol , endocrinology , plasma renin activity , renal artery , agonist , blood pressure , kidney , heart rate , peptide hormone , chemistry , receptor
SUMMARY 1. The effect of atrial natriuretic peptide (ANP) on α‐adrenoceptor agonist‐induced renin release was examined in the de‐ennervated kidney of the anaesthetized dog pretreated with propranolol (1 mg/kg, intravenous). 2. Phenylephrine (50 ng/kg per min) infused into the renal artery increased the renal secretion rate of renin (RSR) without affecting systemic blood pressure or renal blood flow. 3. Although basal RSR was unaffected, the phenylephrine‐induced increase in RSR was abolished during intrarenal arterial infusion of ANP (10 ng/kg per min). 4. The results suggests that exogenously administered ANP could suppress α‐adrenoceptor‐mediated renin release in the dog.