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INFLUENCE OF NEONATAL HYPOTHYROIDISM ON ADRENAL TYROSINE HYDROXYLASE ACTIVATION IN THE YOUNG RAT
Author(s) -
Valens M.,
Gripois D.
Publication year - 1990
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1990.tb01333.x
Subject(s) - endocrinology , medicine , tyrosine hydroxylase , basal (medicine) , insulin , dopamine
SUMMARY 1. Adrenal TH activation was elicited in young rats (aged 4,6 and 14 days) by insulin hypoglycaemia. In the control rats, TH activation varied between 125 and 147% above basal values. 2. Neonatal hypothyroidism induced by PTU treatment impaired TH activation. Compensatory treatment with T 3 to the PTU‐treated young rats led to a return to control activation.