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PREVENTION OF ARTERIAL DISEASE IN EXPERIMENTAL RENAL HYPERTENSION
Author(s) -
Yong A. C.,
Boyd G. W.
Publication year - 1990
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1990.tb01323.x
Subject(s) - medicine , cardiology
XUMMARY 1. This study examined the effect of various antihypertensive agents on the development of polyarteritis nodosa lesions along the mesenteric artery system over a 10 week period after renal artery clipping in uninephrectomized rats (lKlC). 2. Of the agents, only hydralazine, enalapril and diltiazem significantly inhibited systolic blood pressure (SBP) rise over the 10 week period ( P <0.001). 3. All agents except hydralazine reduced the severity of arteritic lesions compared with lKlC rats, but only with enalapril ( P <0.001), nifedipine ( P <0.001), diltiazem ( P <0.005), propranolol ( P <0.001) and reserpine ( P <0.05) was this reduction statistically significant. 4. There was a positive correlation between the degree of arteritic change and SBP, but the correlation coefficient was neither high ( r = 0.68) nor highly significant ( P = 0.03, d.f. = 9). On examining the data, this was due on the one hand to nifedipine, propranolol and reserpine reducing the severity of lesions without significantly inhibiting SBP, and on the other to hydralazine reducing SBP without significantly affecting the extent of arteritic change. 5. These findings suggest that factors other than mere SBP alone are involved in the pathogenesis of these arteritic lesions.