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MECHANISMS INVOLVED IN THE STIMULATION OF ALDOSTERONE PRODUCTION BY ANGIOTENSIN II, VASOPRESSIN AND ENDOTHELIN
Author(s) -
Woodcock Elizabeth A.,
Tanner Jennifer K.,
Caroccia Lucy M.,
Little Peter J.
Publication year - 1990
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1990.tb01318.x
Subject(s) - medicine , aldosterone , endocrinology , angiotensin ii , vasopressin , stimulation , endothelin 1 , inositol phosphate , chemistry , renin–angiotensin system , peptide hormone , phosphatidylinositol , zona glomerulosa , inositol , biology , hormone , receptor , signal transduction , biochemistry , blood pressure
SUMMAY 1. Endothelin (ET), vasopressin (VP) and angiotensin II (AII) all stimulate aldosterone production in adrenal glomerulosa cells but the response to AII is greater than that to either ET or VP. 2. Total inositol phosphate responses to AII and ET were similar but the response to VP was lower. 3. Cytosolic free Ca 2+ responses to AII were higher than to either of the other peptides. 4. Metabolism of 145IP 3 was different under stimulation by the three different peptides. 5. Adrenal glomerulosa cells can distinguish between three different agonists which stimulate phosphatidylinositol turnover and produce a selective response to each peptide.