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HAEMODYNAMIC EFFECTS OF LONG‐TERM ENDOTHELIN INFUSION IN CONSCIOUS SHEEP
Author(s) -
Reid Amanda F.,
Parkes David G.,
Coghlan John P.,
Scoggins Bruce A.,
Whitworth Judith A.
Publication year - 1990
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1990.tb01314.x
Subject(s) - vasoconstriction , hemodynamics , endothelin receptor , cardiac output , endothelin 1 , mean arterial pressure , blood pressure , vascular resistance , peripheral resistance , endothelin 3 , anesthesia , medicine , endothelins , cardiology , heart rate , receptor
SUMMARY 1. Synthetic human endothelin‐1 was infused intravenously at 15 μg/h for 24 h to examine its cardiovascular actions in five conscious sheep. 2. Endothelin produced a maximum increase in mean arterial pressure (MAP) of + 8 mmHg at 8 h, with an increase in calculated total peripheral resistance (CTPR) of +2.6 mmHg/L per min, whilst cardiac output (CO) was unchanged. At 24 h MAP was not significantly elevated, however CTPR had increased by +2.8 mmHg/L per min and CO had decreased by 0.9 L/min. 3. This study shows that long‐term administration of endothelin produces sustained arterial vasoconstriction in sheep.