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HYPERLIPIDAEMIA INCREASES ALBUMINURIA IN HYPERTENSIVE AND NORMOTENSIVE RATS
Author(s) -
Cooper M. E.,
Vranes D. A.,
Panagiotopoulos S.,
Allen T. J.,
Goodall I.,
Jerums G.
Publication year - 1990
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1990.tb01311.x
Subject(s) - albuminuria , endocrinology , medicine , excretion , triglyceride , cholesterol , albumin , nephropathy , chemistry , kidney , diabetes mellitus
SUMMARY 1. The effects of a high cholesterol diet on urinary albumin excretion were examined in spontaneously hypertensive (SHR) and Wistar‐Kyoto (WKY) rats over 36 weeks. 2. Cholesterol feeding resulted in an increase in total‐cholesterol and a decrease in HDL‐cholesterol without influencing triglyceride levels in both strains. 3. Urinary albumin excretion was significantly elevated in cholesterol‐fed SHR and WKY rats. 4. These results suggest that hyperlipidaemia may be important in acceleration of experimental nephropathy.