Premium
EFFECT OF CGS 9896 ON STRESS‐INDUCED GASTRIC ULCER IN RAT
Author(s) -
Najim Rafid A.,
Karim Kassim H.
Publication year - 1990
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1990.tb01298.x
Subject(s) - chlordiazepoxide , benzodiazepine , sedative , agonist , medicine , pharmacology , partial agonist , antagonist , anesthesia , diazepam , receptor
SUMMARY 1. The effects of CGS 9896, a partial benzodiazepine agonist, and chlordiazepoxide, a full benzodiazepine agonist, on stress‐induced gastric ulcers as well as blood glucose were compared. 2. Ulceration in the glandular stomach was induced by 2 h restraint at 4°C. 3. CGS 9896 reduced significantly the ulcer parameters but did not affect blood glucose. The effect of CGS 9896 was dose‐dependently blocked by the benzodiazepine antagonist flumazepil. 4. Chlordiazepoxide reduced the ulcer parameters but increased blood glucose. 5. Since CGS 9896 lacks sedative effects but reduced ulcer parameters, the antiulcer and sedative effects of drugs acting at benzodiazepine receptors are disassociated. 6. Benzodiazepine‐induced hyperglycaemia does not play a major role in the antiulcer effects.