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RAT DUODENAL SMOOTH MUSCLE CONTRACTILE RESPONSES TO ANGIOTENSIN II ARE DEPENDENT ON CALMODULIN
Author(s) -
Weekley L. Bruce
Publication year - 1990
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1990.tb01292.x
Subject(s) - calmodulin , motility , angiotensin ii , endocrinology , medicine , smooth muscle , renin–angiotensin system , chemistry , biology , calcium , microbiology and biotechnology , blood pressure
SUMMARY 1. Isolated duodenal segments were pretreated with either of the calmodulin inhibitors proadifien or trifluoroperazine and the subsequent contractile force and frequency response to angiotensin II monitored. 2. Both proadifien and trifluoroperazine decreased the spontaneous contractile force and frequency in isolated perfused duodenal segments and attenuated the force generation following exposure to angiotensin II. Proadifien and trifluoroperazine also altered the qualitative behaviour of duodenal segments. 3. These results suggest that the action of angiotensin II on duodenal smooth muscle motility is dependent on calmodulin. Furthermore, the change in qualitative behaviour of duodenal segments following treatment with calmodulin inhibitors suggest that the function of intrinsic intestinal neurons is also altered.