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EFFECT OF ACETYLCHOLINE AND MORPHINE ON BRONCHIAL SMOOTH MUSCLE CONTRACTION AND ITS MODULATION BY STEROID HORMONES
Author(s) -
Nabishah B. M.,
Morat P. B.,
Khalid B. A. K.,
Kadir B. A.
Publication year - 1990
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1990.tb01287.x
Subject(s) - acetylcholine , contraction (grammar) , muscarinic acetylcholine receptor , endocrinology , morphine , medicine , corticosterone , chemistry , glucocorticoid , steroid , dexamethasone , hormone , corticosteroid , receptor
SUMMARY 1. The effects of corticosteroid pretreatment on acetylcholine (ACH)‐induced contraction of bronchial smooth muscle (BSM) were studied. 2. ACH dose‐response curves for dexamethasone (DM)‐ and corticosterone (B)‐treated but not deoxycorticosterone (DOC)‐treated BSM were significantly shifted to the right; this provides evidence that glucocorticoid treatment reduced the sensitivity of BSM to ACH. 3. Morphine enhanced BSM contraction in response to ACH by 20%. DM suppressed this enhancement. 4. These findings correlated well with the reduction of muscarinic receptor numbers in BSM by glucocorticoids in our previous study. In addition, glucocorticoids reduced the sensitivity of BSM to opioids.