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EFFECT OF ETHAMSYLATE ON CARRAGEENAN‐INDUCED RAT PAW OEDEMA: A COMPARISON WITH INDOMETHACIN
Author(s) -
Gard P. R.,
Trigger D. J.
Publication year - 1990
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1990.tb01285.x
Subject(s) - carrageenan , chemistry , pharmacology , potency , mechanism of action , prostaglandin , medicine , in vitro , biochemistry
SUMMARY 1. Ethamsylate (diethylammonium 2,5‐dihydroxybenzene sulfonate, Dicynene TM ), a systemic haemostatic agent with an unknown mechanism of action, was tested for anti‐inflammatory activity using the carrageenan‐induced rat paw oedema test. 2. Ethamsylate was shown to be an effective anti‐inflammatory agent with a time course and amplitude of effect similar to that of indomethacin, although the potency was only about 4% of that for indomethacin. 3. When ethamsylate and indomethacin were co‐administered they did not show additive effects, suggesting that they do not share a common mode of action. It is proposed that ethamsylate, like indomethacin, may inhibit prostaglandin synthesis.