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LACK OF EFFECT OF GRANULOCYTE‐MACROPHAGE COLONY STIMULATING FACTOR ON THE RAT AORTA OR HUMAN SAPHENOUS VEIN
Author(s) -
Watabe T.,
Moulds R. F. W.
Publication year - 1990
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1990.tb01281.x
Subject(s) - vein , macrophage , granulocyte macrophage colony stimulating factor , aorta , medicine , granulocyte , chemistry , endocrinology , cytokine , biochemistry , in vitro
SUMMARY 1. In order to assess whether the observed hypotensive response in some patients given human granulocyte‐macrophage colony stimulating factor (GM‐CSF) is caused by a direct vascular effect of the GM‐CSF, the effects of mouse and human GM‐CSF were examined in rat aortic rings and human saphenous veins respectively. 2. No effects of GM‐CSF were observed, either in the presence or absence of endothelium, on responses to the α‐adrenoceptor agonist phenylephrine. 3. These data suggest that GM‐CSF does not have direct effects on either vascular endothelium or smooth muscle, and that a direct vascular effect of GM‐CSF is not the explanation for the observed clinical response.