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INTRACEREBROVENTRICULAR INFUSIONS OF INSULIN INCREASE VASOPRESSIN RELEASE IN RATS
Author(s) -
Nishimura Masato,
Takahashi Hakuo,
Matsusawa Makoto,
Ikegaki Iwao,
Nakanishi Tadashi,
Hirabayashi Masami,
Yoshimura Manabu
Publication year - 1990
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1990.tb01278.x
Subject(s) - vasopressin , medicine , endocrinology , hypothalamus , insulin , arginine , sodium , chemistry , amino acid , biochemistry , organic chemistry
SUMMARY 1. The role of cerebral insulin or insulin‐like immunoreactive substance (ILI) on arginine–vasopressin (AVP) release using rats was investigated. Feeding rats with a high salt diet for 4 weeks significantly decreased the contents of ILI in both the hypothalamus and pituitary gland. Intracerebroventricular infusions of insulin (4 and 40 μg/min for 30 min) increased plasma AVP concentrations dose‐dependently without hypoglycaemia, but decreased hypothalamic and pituitary contents of AVP. 2. These results indicate that ILI in the brain may play a role in the secretion of AVP, and that this mechanism could be operated to control a water–sodium balance.