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VASODILATORY EFFECTS OF MILRINONE ON PULMONARY VASCULATURE IN DOGS WITH PULMONARY HYPERTENSION DUE TO PULMONARY EMBOLISM: A COMPARISON WITH THOSE OF DOPAMINE AND DOBUTAMINE
Author(s) -
Tanaka Hiroyuki,
Tajimi Kimitaka,
Matsumoto Akinori,
Kobayashi Kunio
Publication year - 1990
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1990.tb01267.x
Subject(s) - milrinone , medicine , dobutamine , pulmonary hypertension , inotrope , vasodilation , pulmonary artery , cardiology , pulmonary embolism , pulmonary vasculature , anesthesia , hemodynamics
SUMMARY 1. The limited therapeutic role of pulmonary vasodilation reflects lack of their selectivity for the pulmonary vasculature, and many drugs have been evaluated for effectiveness; however, none has gained widespread clinical use. 2. Milrinone (MIL) is a newly synthetized phosphodiesterase inhibitor, which has potent positive inotropic and vasodilatory effects. 3. The present study shows the effects of MIL on the pulmonary circulation in dogs with pulmonary hypertension due to autologous muscle‐induced pulmonary embolism, and also demonstrates a comparison with those of dopamine and dobutamine. 4. As MIL showed potent vasodilatory effects on the pulmonary vasculature, it had a potential clinical role in the treatment of pulmonary hypertension.