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EFFECTS OF LOW DOSE INFUSION OF ATRIAL NATRIURETIC FACTOR ON ACUTE INHIBITION OF ANGIOTENSIN CONVERTING ENZYME IN NORMAL MAN
Author(s) -
Nakamura Motoyuki,
Arakawa Naoshi,
Kawata Yukio,
Kato Masataka
Publication year - 1990
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1990.tb01260.x
Subject(s) - captopril , medicine , endocrinology , aldosterone , renin–angiotensin system , atrial natriuretic peptide , plasma renin activity , peptide hormone , angiotensin converting enzyme , blood pressure , hormone , enzyme inhibitor , angiotensin ii , placebo , ace inhibitor , chemistry , enzyme , biochemistry , alternative medicine , pathology
SUMMARY 1. We have studied the effects of low dose infusions of atrial natriuretic factor (human ANF (99–126), 1.95 pmol/min per kg) on angiotensin converting enzyme (ACE) inhibitor‐induced haemodynamic and hormonal changes in healthy subjects. 2. ACE inhibitor (captopril 25 mg, administered orally) was given against a background infusion of physiological saline (placebo day) or ANF (experimental day). 3. Compared with the placebo observations, ANF enhanced the fall in plasma aldosterone concentrations induced by captopril ( P <0.05). 4. The rise of plasma renin activity following administration of ACE inhibitor which was observed during placebo infusion was abolished by ANF ( P <0.05). 5. The responses of systemic blood pressure and heart rate to the converting enzyme inhibition were not affected by the infusion of ANF. 6. These results suggest that variations in endogenous circulating ANF may influence, in part, the response of these hormonal levels during ACE inhibition.