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ASSESSMENT OF CARDIOPULMONARY BAROREFLEX FUNCTION IN HYPERTENSIVE AND NORMOTENSIVE SUBJECTS WITH OR WITHOUT HYPERTENSIVE RELATIVES
Author(s) -
Ueda Masahiro,
Nomura Gakuji,
Shibata Hajime,
Nishida Hiromi,
Moriyama Atsuo,
Kumagai Eiichirou,
Toshima Hironori
Publication year - 1989
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1989.tb03000.x
Subject(s) - baroreflex , medicine , cardiology , anesthesia , blood pressure , heart rate
SUMMARY1 To investigate whether cardiopulmonary baroreflex control contributes to the pathogenesis and progression of hypertension, we have evaluated the function of the cardiopulmonary baroreflex in 22 patients with essential hypertension and in 17 volunteers with normotension. The normotensi ve group consisted of 8 subjects with a family history of hypertension and nine with no family history. 2 Forearm vascular resistance (FVR) and central venous pressure (CVP) were measured under control conditions when – 10 mmHg lower body negative pressure was applied; the cardiopulmonary slope (CPS = AFVR/ACVP) was calculated as an index of the cardiopulmonary baroreflex function. 3 CPS was significantly higher in hypertensives (6.0±3.93 [s.d.], P<0.01 and also tended to be higher in normotensives with a family history of hypertension (3.9±3.53, P<0.05), compared with normotensives without a family history of hypertension (1.7±0.88). 4 When the hypertensives were divided into two groups, depending on whether CPS was greater or less than 6.0 units, cardiac wall thickness (20 ± 1.6 mm vs 23 ± 3.2 mm, P<0.05) and the renal vascular resistance (20.9 ± 6.52 units vs 28.9 ± 7.32 units, P<0.05) were both significantly higher in the Low CPS group. 5 These findings suggest that cardiopulmonary baroreflex function was augmented even in normotensive subjects with hypertensive relatives, as compared with those without hypertensive subjects. Furthermore, cardiopulmonary baroreflex function was augmented in the early stages of hypertension and diminished further with increasing severity.