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AGE‐RELATED CHANGES IN BLOOD PRESSURE, HEART RATE AND BAROREFLEX SENSITIVITY IN SHR
Author(s) -
Minami N.,
Imai Y.,
Munakata M.,
Sasaki S.,
Sekino H.,
Abe K.,
Yoshinaga K.
Publication year - 1989
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1989.tb02999.x
Subject(s) - baroreflex , blood pressure , phenylephrine , heart rate , bradycardia , medicine , prehypertension , mean arterial pressure , anesthesia , baroreceptor , cardiology
SUMMARY1 The age‐related changes in mean arterial pressure (MAP), heart rate (HR), and baroreflex sensitivity (BRS) were studied in spontaneously hypertensive rats (SHR) and Wistar‐Kyoto (WKY) rats from 4 to 20 weeks of age. 2 Intra‐arterial blood pressure (BP) was continuously recorded for 24 h in conscious, freely moving rats. Twenty‐four hour MAP and HR were calculated by an online computer. Baroreflex sensitivity was measured by phenylephrine infusion. 3 In SHR, BRS was significantly lower than in WKY as early as 4‐5 weeks, at which time MAP in SHR was only slightly raised. During subsequent weeks, rapid increase in MAP occurred in SHR, in association with progressive bradycardia. 4 It was concluded that a reduced BRS may be detected in young prehypertensive SHR and this impairment of BRS may be central in origin.