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REGIONAL DISTRIBUTION OF THE CARDIAC OUTPUT AND RENAL RESPONSES TO ATRIAL ATRIURETIC PEPTIDE INFUSION IN RABBITS WITH CONGESTIVE HEART FAILURE
Author(s) -
Langton David,
Jover Bernard F.,
Trigg Lisbeth,
Fullerton Meryl,
Blake Duncan W.,
McGrath Barry P.
Publication year - 1989
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1989.tb02405.x
Subject(s) - atrial natriuretic peptide , medicine , cardiac output , heart failure , preload , plasma renin activity , hemodynamics , norepinephrine , cardiology , venous return curve , stroke volume , cardiac function curve , central venous pressure , blood pressure , renal blood flow , endocrinology , blood volume , renin–angiotensin system , heart rate , ejection fraction , dopamine
SUMMARY 1. A biventricular, low‐output congestive cardiomyopathy was induced in 19 rabbits by administering adriamycin (16 mg/kg). The effects of SaL‐rat atrial natriuretic peptide (ANP) infused at 0.1, 0.2 and 0.4 μg/kg per min, were then examined in terms of (i) central haemodynamics (ii) regional blood flow (iii) renal function and (iv) plasma norepinephrine and plasma renin. 2. In this dose range, ANP produced progressive and significant falls in stroke volume, cardiac output and mean arterial pressure, owing to a fall in venous return. The heart rate response to this was blunted. 3. Using radiolabelled microspheres, significant falls in the perfusion of cutaneous, gastrointestinal and musculoskeletal tissues were observed, due to reduced vascular conductances in these beds. These changes were accompanied by activation of the sympathetic nervous system as evidenced by a progressive rise in plasma norepinephrine. A significant increase in plasma renin was only observed with the highest infusion of ANP. 4. Renal blood flow was maintained in the face of a falling mean arterial pressure and cardiac output, but diuretic and natriuretic effects were absent. 5. It was concluded that the dominant influence of ANP infusion in this model of heart failure appeared to be a reduction in cardiac preload with detrimental overall haemodynamic consequences.