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ACUTE HORMONAL AND RENAL EFFECTS OF ORAL DILEVALOL IN NORMAL MEN
Author(s) -
Whitworth Judith A.,
Gordon Deanna,
Harpley Robin,
Yeung Stella,
Phillips Paddy
Publication year - 1989
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1989.tb01909.x
Subject(s) - placebo , plasma renin activity , medicine , aldosterone , blood pressure , renin–angiotensin system , hormone , renal function , atrial natriuretic peptide , endocrinology , alternative medicine , pathology
SUMMARY 1. Acute hormonal and renal effects of dilevalol (200 mg), a non‐selective β‐blocking drug with vasodilator properties, were compared with placebo in six normal men on constant sodium intake. 2. Control and treatment blood pressures were lower with dilevalol than placebo, although the pattern of blood pressure fall was similar in both. 3. Plasma active renin and aldosterone concentrations were lower on dilevalol than placebo after 4 h of recumbency ( P < 0.05). 4. Total plasma renin, renin substrate, cortisol and atrial natriuretic peptide concentrations were similar on dilevalol and placebo. 5. There were no differences in glomerular filtration rate and no deleterious biochemical or haematological changes on dilevalol or placebo.