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COMPARISON OF THE VASCULAR AND GLOMERULAR CHANGES IN AORTIC‐LIGATURE AND DOCA‐SALT HYPERTENSION
Author(s) -
Hewitson Tim,
Kamitsuji Hidekazu,
Whitworth Judith A.,
KincaidSmith Priscilla
Publication year - 1989
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1989.tb01615.x
Subject(s) - ligature , glomerulus , medicine , blood pressure , pathological , fibrinoid necrosis , aortic pressure , endocrinology , cardiology , kidney , vasculitis , disease
SUMMARY 1. Animals and histology from two previous investigations were used to test the hypothesis that a similar elevation in blood pressure may result in a different sequence of pathological changes in different experimental models of hypertension, DOCA‐salt and aortic‐ligature hypertension. 2. To assess differences in morphological parameters, individual animals in the two groups were paired ( n = 12) for the same level of blood pressure at sacrifice. 3. Vascular damage was significantly less in the DOCA‐salt group ( P < 0.01). Glomerular lesions however were more severe in the DOCA‐salt group. In rats with aortic‐ligature hypertension significantly fewer glomeruli had fibrinoid and/or crescents than in DOCA‐salt rats ( P < 0.001). There were fewer glomeruli with epithelial cell droplets (ECD) and fewer ECD per glomerulus in aortic‐ligature when compared with DOCA‐salt hypertension ( P < 0.001, P < 0.001, respectively). 4. This study highlights the significance of factors other than blood pressure per se in producing vessel and glomerular lesions in experimental hypertension.