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MUSCARINIC RECEPTOR DIFFERENTIATION
Author(s) -
Mitchelson F.,
Choo L. K.,
Darroch S.
Publication year - 1989
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1989.tb01599.x
Subject(s) - muscarinic acetylcholine receptor , receptor , muscarinic acetylcholine receptor m1 , muscarinic acetylcholine receptor m5 , muscarinic acetylcholine receptor m4 , muscarinic acetylcholine receptor m2 , muscarinic acetylcholine receptor m3 , chemistry , neuroscience , microbiology and biotechnology , biology , pharmacology , biophysics , biochemistry
SUMMARY 1. Several selective antagonists are available to differentiate between muscarinic receptors. 2. Further subdivision of M 1 and M 2 muscarinic receptors appears possible and is supported by studies with cloned receptors. 3. Reasons for differences between affinity constants determined in functional and binding studies and whether receptor subtypes couple exclusively with a particular cellular mechanism are still to be determined.