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ONCOGENES: PAST, PRESENT AND FUTURE
Author(s) -
Klinken S. Peter
Publication year - 1989
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1989.tb01596.x
Subject(s) - proto oncogenes , biology , gene , chromosomal translocation , signal transduction , microbiology and biotechnology , intracellular , transcription (linguistics) , genetics , cancer research , oncogene , cell cycle , linguistics , philosophy
SUMMARY 1. Certain retroviruses contain specific genes (oncogenes) which induce tumours. 2. These viral genes were shown to have normal counterparts in the mammalian genome which were termed proto‐oncogenes or cellular oncogenes. 3. This breakthrough provided a molecular explanation for tumour formation; viz. cells become transformed when regulation of cellular oncogenes goes awry. 4. Evidence for aberrant control of proto‐oncogenes in human malignancies was obtained when chromosomal translocations in Burkitt's lymphomas and chronic myelogenous leukaemia localized to the myc and abl cellular oncogenes, respectively. 5. Recent studies have demonstrated that proto‐oncogenes govern cellular proliferation and can be from any part of the signal transduction pathway, for example, growth factors, receptors, intracellular second messengers or nuclear transcription regulators.