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NORADRENALINE DIFFUSION, METABOLISM AND VASCULAR RESPONSE IN THE RABBIT EAR ARTERY
Author(s) -
Lande I. S.
Publication year - 1989
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1989.tb01588.x
Subject(s) - normetanephrine , constriction , distension , human ear , chemistry , medicine , artery , endocrinology , catecholamine , biophysics , biology , physics , acoustics
SUMMARY 1. Effects of uptake 1 and uptake 2 inhibition on the vasoconstrictor activity of noradrenaline (NA) in the perfused artery of the rabbit ear are reviewed in the light of data on NA metabolism and diffusion. 2. The minor effect of uptake 1 inhibition on the response to intraluminal NA is related to location of the sympathetic nerves at the medial‐adventitial border, and low diffusivity together with loss of amine by uptake 2 in the media. 3. The minor effect of uptake 2 inhibition on the vasoconstrictor activity of NA suggests that uptake 2 has little effect on steady‐state amine concentration in the media. This suggestion is supported by analyses of patterns of normetanephrine efflux from the artery. 4. Attention is drawn to the ability of uptake inhibitors, and of constriction and distension, to influence entry of NA into the artery wall.