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MECHANISMS OF ADAPTIVE SUPERSENSITIVITY IN SMOOTH MUSCLES VS CARDIAC MUSCLE: A BRIEF REVIEW
Author(s) -
Fleming William W.
Publication year - 1989
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1989.tb01585.x
Subject(s) - adenylate kinase , cyclase , receptor , endocrinology , medicine , chemistry , guinea pig , microbiology and biotechnology , neuroscience , biology
SUMMARY 1. Depending upon the type of cell being studied, adaptive supersensitivity has been traced to molecular changes in receptors, the Na+/K+ pump or the G‐protein/adenylate cyclase system. 2. Evidence is reviewed that indicates that adaptive supersensitivity in guinea‐pig atria is the result of changes in the G‐protein/adenylate cyclase system.