Premium
BLOOD PRESSURE RESPONSE TO NOREPINEPHRINE AND ANGIOTENSIN II IN THE OFFSPRING OF PARATHYROIDECTOMIZED MOTHER RATS
Author(s) -
Nakanishi Hitoshi,
Fujii Tomoko
Publication year - 1989
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1989.tb01575.x
Subject(s) - norepinephrine , offspring , endocrinology , medicine , blood pressure , angiotensin ii , pressor response , chemistry , biology , pregnancy , dopamine , heart rate , genetics
SUMMARY 1. The basal blood pressure and the drug‐stimulated pressor response were studied in male offspring in the sixth generation (5d‐PTx‐F 6 ) of rats parathyroidectomized on day 5 of pregnancy. 2. The systolic blood pressure in conscious 5d‐PTx‐F 6 rats measured by a tail cuff was significantly higher ( P < 0.001) than in control rats. 3. Venous plasma renin activity was significantly lower ( P < 0.001) in the 5d‐PTx‐F 6 rats. Plasma levels of calcium, sodium, and potassium in the 5d‐PTx‐F 6 rats and in the controls did not differ. 4. Systolic arterial pressure response to intravenously (i.v.) administered angiotensin II (150 ng/kg) in the 5d‐PTx‐F 6 rats was significantly greater than in the controls ( P < 0.05), when blood pressure was measured directly through a pressure transducer under anaesthesia. 5. Pressor responses to norepinephrine (5 μg/kg, i.v.) in the 5d‐PTx‐F 6 rats were significantly lower ( P < 0.05) than in the controls, when blood pressure was measured directly under anaesthesia. 6. The findings suggest that the 5d‐PTx‐F 6 rats undergo functional alterations of the renin‐angiotensin and sympathetic nervous systems for cardiovascular regulations.