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HYPOTHERMIA ENHANCES THE EFFECTS OF MORPHINE ON HORMONAL AND HISTAMINE RELEASE
Author(s) -
Alcaraz Cristina,
Bansinath Mylarrao,
Turndorf Herman,
Puig Margarita M.
Publication year - 1989
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1989.tb01573.x
Subject(s) - morphine , histamine , hypothermia , (+) naloxone , endocrinology , hormone , medicine , chemistry , opioid , receptor
SUMMARY 1. The effects of intravenous (i.v.) morphine on adrenocorticotrophic hormone (ACTH), β‐endorphin (β‐END), total catecholamines (CA) and histamine (HIS) plasma concentrations, were determined in anaesthetized dogs at 30°C and 37°C. 2. Hypothermia initially increased CA levels by 29%, but the values returned to baseline after 2 h. Morphine (1 mg/kg, i.v.) produced a significant decrease in CA both at 37°C and 30°C (34% and 54%, respectively). Subsequent administration of naloxone (1 mg/kg, i.v.) significantly increased CA levels in both groups. 3. Hypothermia per se had no effect on ACTH, β‐END, and HIS concentrations. Morphine produced a significant increase in pituitary hormones and HIS, in hypo‐ thermic but not in normothermic animals. Morphine concentrations were significantly higher at 30°C during the first 45 min. 4. The results suggest that the effects of morphine on hormonal and histamine release observed at 30°C are concentration‐dependent and related to changes in morphine pharmacokinetics.